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Cortisone injected into local areas such as hip and shoulder are usually well-tolerated and are less likely than other types of steroid medications to produce serious side effects, according to a 2014 study of more than 1 million patients. "The key issue we don't have is any evidence of any harm of cortisone for people who need it for other reasons," said Dr. Robert G. Krieger, senior vice president at Medtronic, which has about 2,200 employees and operates more than 100 clinics in Ohio. The company and its U.S. rival, Bristol Myers Squibb, did not respond to interview requests. In the Ohio study, people who needed the drug most often were the lowest in the county at about 9% who used it regularly, compared with the national average of about 25%. But in the national data, those people accounted for 30% of all injectors. Krieger said Medscape Medical Group was unaware of the study, but said his company had heard of some of the findings but had no plans to begin making a new formulation of the drug. (See "Medscape's $4 Billiards Set") The drug is also effective for preventing heart attack, but can worsen other medical problems such as joint pain and bone, hip and neck problems, according to Cleveland Clinic. As with steroid steroids, cortisone lowers cholesterol, blood sugar and triglycerides. But when combined with other medications that lower blood sugar, heart attacks become more likely. As a result, cardiovascular death rates among men and women have nearly doubled from 2002 to 2013, the National Safety Council reports. "It seems crazy that we've become so reliant on the overproduction of this steroid, in terms of the need we all feel," said Dr. David D. Cohen, a cardiologist with Kaiser Permanente in San Francisco. "We can easily get it on a prescription when the need is very rare or when it is a good idea based on risk." Krieger is part of a team that won a 2014 FDA grant to investigate a potential combination product, called Medscape-Plus, that involves an oral steroid with a glucose control drug. But a trial of the product in 10 U.S. clinics found higher rates of drug resistance than among people who did not take the meds. Patients who got the product also had an increased risk of blood clots and stroke, according to the agency's report. Another trial this year found only minor changes in the risk of stroke in patients who were assigned to receive Medscape Plus rather than using an oral steroid. Other researchers have concluded no Similar articles: